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. 2005 Mar 30;25(13):3358–3368. doi: 10.1523/JNEUROSCI.4227-04.2005

Figure 1.

Figure 1.

Effects of BDNF on eIPSC and mIPSC GABAergic currents recorded at the soma of whole-cell-clamped hippocampal neurons. A, Left, eIPSCs recorded from 14-21 DIV neurons under control conditions, with BDNF and BDNF plus anti-TrkB IgG1 (Vh = -70 mV). Right, Mean amplitude of eIPSCs in the conditions and number of neurons indicated; **p < 0.01 versus controls and anti-TrkB IgG1 plus BDNF using one-way ANOVA. B, Consecutive recordings of mIPSCs in 20 DIV control neurons (left) and 20 DIV BDNF-treated neurons (4 d without plus 16 d with BDNF) (right); Vh = -70 mV. C, Mean frequency of mIPSCs calculated from groups of 14-21 DIV control and BDNF-treated neurons. *p < 0.02 versus controls. D, Overlapped amplitude distributions of mIPSCs from the same two neurons in B. BDNF causes a consistent increase in the occurrence of events (filled bars). E, Mean amplitudes of mIPSCs calculated from groups of 14-21 DIV control and BDNF-treated neurons (the number of neurons for each condition is indicated in each bar).