Figure 6.

L-LTP induced by β-adrenergic receptor activation paired with subthreshold stimulation does not exhibit a late transcriptional component. A, Application of ISO during 5 Hz stimulation induces L-LTP, which lasts for at least 6 h (open circles). B, L-LTP is maintained for at least 6 h when ACT-D is applied during ISO plus 5 Hz stimulation (filled squares). C, Summary histogram comparing potentiation levels of slices treated with or without ACT-D at various time points. All sample traces were taken 10 min after commencement of baseline recording and 120 min after stimulation protocol. Calibration: 5 mV, 2 ms.