Figure 3.

Postsynaptic factors contribute only slightly to the discrepancy in RRP estimates. A, Representative EPSCs in the presence and absence of 25 μm GYKI 52466. B, Representative EPSCs in the presence of 0, 200, and 1000 μm kynurenate. A, B, Presynaptic stimulus transients have been blanked for clarity. C, Summary of train estimates of RRP size, expressed as percentages of sucrose estimates of RRP size performed in the same neurons, in control conditions and in the presence of 25 μm GYKI 52466 (GYKI) or kynurenate (kyn). ^*p < 0.03 compared with train estimates made in control conditions; in all conditions, train estimates were significantly different from sucrose estimates made in the same neurons (n = 5-13 in each condition). Error bars represent SEM.