Figure 2.
Results from choline uptake assays and correlations with performance. A, Compared with NP controls, the capacity of the CHT to transport choline (as indicated by Vmax) was increased in the right but not left mPFC (the asterisk depicts the significant difference indicated by post hoc multiple comparisons using Tukey's honestly significant difference) of CVT-performing rats. B, Results from saturation analyses depicting hemicholinium-sensitive choline uptake by synaptosomes obtained from right mPFC from animals of the three groups. The inset shows the approximate location and extent of the prefrontal and parietal cortical tissue extracted for these experiments (the more ventral portions of the mPFC are not visible). C, Right mPFC Vmax values correlated significantly with the animal's ability to detect 500 ms signals (filled circles and positive slope regression line), whereas left PFC Vmax scores correlated negatively with this measure (open circles and negative slope regression line; see Results for statistical results).