Table 2.
Genes changed after hypoxia that are common to HIF-1αF/F and HIF-1αΔ/Δ
|
Probe set |
Gene title |
Avg ratio (FC) (WT:MUT) |
Avg chg p value (WT:MUT) |
Gene symbol |
|---|---|---|---|---|
| 94881_at | cyclin-dependent kinase inhibitor 1A (p21) | 3.4:3.8 | 6.92e-3:2.24e-3 | Cdkn1a |
| 103520_at | vascular endothelial growth factor A | 2.5:2.0 | 1.95e-2:2.24e-2 | Vegfa |
| 100569_at | annexin A2 | 2.4:2.2 | 9.12e-3:5.01e-3 | Anxa2 |
| 98067_at | cyclin-dependent kinase inhibitor 1A (p21) | 2.4:2.7 | 4.27e-3:1.20e-3 | Cdkn1a |
| 161817_f_at | RIKEN cDNA 4930422J18 gene | 2.4:2.2 | 8.51e-3:4.47e-3 | |
| 161013_f_at | RIKEN cDNA 4930422J18 gene | 2.2:2.4 | 4.47e-2:3.02e-2 | 4930422J18Rik |
| 93284_at | cold inducible RNA binding protein | 2.1:1.9 | 2.00e-3:1.62e-3 | Cirbp |
| 101979_at | gadd 45γ | 2.1:2.6 | 3.89e-3:2.95e-3 | Gadd45g |
| 93619_at | period hom log 1 (Drosophila) | 2.0:1.7 | 9.33e-3:1.38e-2 | Per1 |
| 93294_at | connective tissue growth factor | 2.0:1.6 | 1.26e-2:6.31e-2 | Ctgf |
| 101889_s_at | RAR-related orphan receptor α | 2.0:1.3 | 1.95e-2:9.33e-2 | Rora |
| 101430_at | SRY-box containing gene 4 | 2.0:1.9 | 2.00e-2:1.02e-2 | Sox4 |
| 93974_at | RIKEN cDNA 1300002F13 gene | 1.9:1.9 | 3.09e-3:6.61e-3 | 1300002F13Rik |
| 94288_at | histone 1, HIc | 1.9:2.2 | 9.77e-3:4.57e-3 | Hist1hlc |
| 93527_at | basic transcription element binding protein 1 | 1.9:1.5 | 1.26e-2:1.23e-2 | Bteb 1 |
| 96841_at | proviral integration site 3 | 1.9:1.9 | 2.57e-3:2.40e-3 | Pim3 |
| 96348_at | RIKEN cDNA 0610039C21 gene | 1.8:2.0 | 1.86e-2:4.17e-3 | 0610039C21Rik |
| 160109_at | SRY-box containing gene 4 | 1.7:1.9 | 7.41e-3:8.32e-3 | Sox4 |
| 104149_at | NFκ inhibi or, α | 1.7:1.9 | 1.51e-2:1.10e-2 | Nfkbia |
| 94297_at | FK506 bincing protein 5 | 1.5:1.8 | 3.72e-3:1.51e-3 | Fkbp5 |
| 96747_at | ras homolog gene family, member U | 1.4:1.9 | 4.90e-2:9.77e-4 | Arhu |
| 100133_at | Fyn proto-oncogene | 1.4:1.6 | 4.37e-2:1.70e-2 | Fyn |
| 92202_g_at | Mus musculus similar to Zinc finger protein 145 | 1.4:1.6 | 3.31e-2:8.71e-4 | |
| 102983_at | MAD homolog 1 (Drosophila) | 1.4:1.6 | 1.29e-1:8.71e-3 | Madh1 |
| 95731_at | Mus musculus Sestrin 1 mRNA | 1.3:1.6 | 9.12e-3:1.58e-3 | Sesn1 |
| 96103_f_at | RAD23b homolog (Saccharomyces cerevisiae) | 1.3:1.7 | 1.86e-1:2.40e-2 | Rad23b |
| 96920_at | protease, serine, 11 (Igf binding) | 1.3:1.8 | 2.34e-2:1.58e-3 | Prss11 |
| 94395_at | DNA segment, Chr 3, ERATO Doi 330 | −1.2:−2.1 | 5.50e-2:4.90e-3 | D3Ertd330e |
| 92338_f_at | RIKEN cDNA 2310001H12 gene | −1.3:−2.0 | 1.41e-1:8.91e-3 | |
| 95393_at | BTB (POZ) domain containing 3 | −1.4:−2.0 | 2.88e-2:2.09e-3 | Btbd3 |
| 98761_i_at | zinc finger protein 97 | −1.4:−2.4 | 1.23e-1:1.66e-3 | Zfp97 |
| 160857_at | ephrin B2 | −1.5:−1.6 | 2.19e-2:1.51e-2 | Efnb2 |
| 160682_at | hypothetical protein A730008H23 | −1.5:−1.7 | 1.45e-2:2.04e-2 | |
| 95050_at | CHORD-containing, zinc-binding protein 1 | −1.6:−1.9 | 8.71e-3:2.00e-3 | Chordc1 |
| 103081_at | bromodomain adjacent to zinc finger domain, 1B | −1.6:−1.5 | 2.14e-3:8.91e-3 | Baz1b |
| 99467_at | RAS p21 protein activator 1 | −1.6:−1.9 | 9.33e-3:6.76e-3 | Rasa1 |
| 99070_at | conserved helix-loop-helix ubiquitous kinase | −1.7:−2.0 | 8.51e-3:1.82e-3 | Chuk |
| 92243_at | RIKEN cDNA B930007L02 gene | −1.7:−1.6 | 3.63e-3:6.92e-3 | 1810017N16Rik |
| 99532_at | transducer of ErbB-2.1 | −1.7:−1.4 | 2.63e-3:2.24e-2 | Tob1 |
| 102318_at | sialyltransferase 8 (α-2, 8-sialytransferase) D | −1.7:−2.3 | 2.51e-2:3.16e-3 | Siat8d |
| 98478_at | cyclin G2 | −1.8:−1.7 | 7.24e-4:7.94e-3 | Ccng2 |
| 93274_at | CDC-like kinase | −1.8:−2.4 | 2.40e-3:7.41e-4 | Clk |
| 93290_at | purine-nucleoside phosphorylase | −1.8:−2.0 | 3.72e-3:3.55e-3 | Pnp |
| 93169_at | RIKEN cDNA 9630054P07 gene | −1.8:−2.2 | 6.17e-3:1.86e-3 | 9630054P07Rik |
| 102397_at | core-binding factor, runt domain, α subunit 2 | −1.8:−1.9 | 3.80e-2:1.17e-2 | Cbfa2t3h |
| 93104_at | B-cell translocation gene 1, anti-proliferative | −2.0:−1.7 | 1.32e-2:4.07e-3 | Btg1 |
| 97848_at | RNA binding motif protein, X chromosome | −2.1:−3.7 | 1.55e-2:1.55e-3 | Rbmx |
| 97142_at | Mus musculus transcribed sequences | −2.2:−2.8 | 5.37e-2:3.72e-3 | |
| 104694_at |
similar to zinc finger protein 40 |
−2.3:−2.7 |
4.17e-2:1.51e-2 |
LOC224598 |
WT indicates HIF-1αF/F; MUT indicates HIF-1αΔ/Δ; Avg ratio (FC) indicates the average fold change; Avg chg p value is the p value (paired, two-tailed) calculated using the nonparametric Wilcoxon's signed rank test (relative).