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. 2005 Apr 20;25(16):4169–4180. doi: 10.1523/JNEUROSCI.0590-05.2005

Figure 3.

Figure 3.

YAC128 mice show decreased intersession open-field habituation. The activity of 8-month-old mice in an open field was tested once per day for 2 d, followed by three trials on the third day. Mice that recognized the open field is not a novel environment showed less activity with each trial. A, The activity of WT mice declined more rapidly than the activity of YAC128 mice, but both groups showed decreased activity over repeated trials (trial: F(4,92) = 60.8, p < 0.001; genotype by trial: F(4,92) = 2.5, p = 0.04; genotype: F(1,23) = 4.8, p = 0.04). Error bars represent SEM. **p < 0.01. B, YAC128 mice are hypoactive at 8 months of age as indicated by an initial 18% difference in activity between YAC128 and WT mice. With repeated open-field trials, the difference in activity between WT and YAC128 mice progressively decreased to 5% by the last trial. Examining the rate of decrease in activity per trial demonstrates that WT mice showed a more rapid habituation than YAC128 mice (WT, 38.8 ± 5.0 beam breaks/trial; YAC128, 26.2 ± 3.2 beam breaks/trial; p = 0.05; n = 12 WT, 13 YAC128).