Skip to main content
. 2005 Jun 8;25(23):5488–5501. doi: 10.1523/JNEUROSCI.1187-05.2005

Figure 6.

Figure 6.

Inhibition of ERK prevents the 5-HT1A reduction of NMDAR currents. A, Plot of peak NMDAR currents showing that 8-OH-DPAT (DPAT; 40 μm) failed to modulate NMDAR currents in the presence of the MEK inhibitor U0126 (20 μm). B, Representative current traces taken from the records used to construct A (at time points denoted by #). Calibration: 100 pA, 1 s. C, Plot of peak NMDAR currents as a function of time and agonist (8-OH-DPAT, 20 μm) application in a GFP-positive neuron transfected with dnMEK1 and a GFP-positive neuron transfected with wtMEK1. D, Representative current traces taken from the records used to construct C (at time points denoted by #). Calibration: 100 pA, 1 s. E, Cumulative data (mean ± SEM) showing the percentage reduction of NMDAR currents by 8-OH-DPAT in a sample of neurons in the absence (ctl) or presence of different MEK inhibitors, as well as in a sample of GFP-positive neurons transfected with dnMEK1 or wtMEK1. The number of cells tested in each condition is shown in each bar. *p < 0.005, ANOVA. ctl, Control.