Figure 9.
Activation of 5-HT1A receptors decreases the surface NR2B clusters on dendrites. A-F, Immunocytochemical images of surface NR2B in transfected PFC cultures treated without (ctl) or with 8-OH-DPAT (DPAT; 40 μm, 5 min) in the absence or presence of the 5-HT1A receptor antagonist NAN-190 (NAN; 2 μm) or the microtubule stabilizer taxol (10 μm). Enlarged versions of the boxed regions of dendrites are shown beneath each of the images. G, Quantitative analysis of surface NR2B clusters (cluster density, cluster size, and cluster intensity) along dendrites under different treatment. *p < 0.01, ANOVA. ctl, Control.