Figure 7.
The S-phase associated cell-cycle molecules ki67 and cyclin D1 are detectable in htau neurons. Brains from age-matched wild-type mice were not reactive with antibodies to ki67 (A), but sections from htau mice showed numerous positive neurons in the cortex (B) and thalamus (C). In wild-type mice, there was no reactivity with cyclin D antibodies (D), and select populations of neurons in htau mice were positive, shown here in the cortex (E) and thalamus (F) of a 22-month-old mouse. Scale bars, 10 μm. Very similar results have been obtained in 12- and 18-month-old htau mice.