Figure 5.

Increased c-Fos IR in the PVN of wild-type and TNFα knock-out mice exposed to a psychogenic stressor (open field). Relative to wild-type mice challenged with SEA (A), similarly challenged TNFα knock-out mice failed to increase c-Fos IR in the PVN (B) but displayed a robust increase after exposure to the open field (OF; C). D, Quantitation of the number of c-Fos-immunoreactive cells in wild-type and TNFα knock-out mice revealed no differences in magnitude of responsiveness to open-field exposure (each bar represents mean ± SE for n = 5 animals). Magnification, A-C, 10×.