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. 2005 May 4;25(18):4540–4549. doi: 10.1523/JNEUROSCI.0492-05.2005

Figure 4.

Figure 4.

Parameters affecting Edn2 and Ednrb transcript induction in response to light damage. A-E, RNA blots showing retinal Edn2 and Ednrb transcript accumulation as follows: A, BALB/c in response to 1 h bright light exposure with pupil dilation, followed by the indicated number of hours of recovery in darkness; B, BALB/c in response to 10 h bright light exposure without pupil dilation, followed by 24 h of recovery in darkness; C, pigmented 129/SVJ in response to the indicated times of bright light exposure with pupil dilation, followed by 24 h of recovery in darkness; D, BALB/c in response to 5, 15, 30, or 60 min bright light exposure with pupil dilation, followed by 24 h of recovery in darkness; E, BALB/c either preconditioned for 10 d in constant light (CL; 250 lux) or maintained in darkness (DA, dark adapted) and then exposed for 1 h to 6000 lux with pupil dilation, followed in each case by 24 h of recovery in darkness. Also shown are Spp1 transcripts, a marker for invading microglia and/or macrophages, and Prcad transcripts, a photoreceptor-specific marker. With respect to the blots in A and B, additional experiments show that, for BALB/c mice, a 1 h exposure with pupil dilation produces a transcript induction response equivalent to that of a 6 h exposure without dilation (data not shown).