Figure 1.
Levels of NA, DA, and 5-HT in the left cerebral cortex of saline-treated rats (c; n = 27) and rats treated effectively with DSP-4 (4; n = 16). NA, DA, and 5-HT were measured using HPLC with electrochemical detection. Values (mean ± SEM) in DSP-4-treated rats are expressed as percentage relative (rel.) to saline-treated controls (100%). NA, 8.8 ± 2.0; DA, 87 ± 20; 5-HT, 83 ± 7. Boxes, Mean ± SEM; open circles, outliers; crosses, extremes. Mann-Whitney U test: NA, p < 0.00001; DA, p = 0.97; 5-HT, p = 0.12.