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. 2005 Jun 29;25(26):6208–6212. doi: 10.1523/JNEUROSCI.4785-04.2005

Figure 2.

Figure 2.

Conditioned morphine withdrawal decreased the activity of brain reward systems. A, Percentage of change from baseline ICSS thresholds ± SEM in morphine-dependent paired rats on the preconditioning day (Pre), during the cue/injection pairings (Naloxone + Cues), and on the test day (Test) when rats were presented with the cues and injected with saline. ###p < 0.001, main effect of naloxone/cues on reward thresholds in conditioned rats (one-way repeated-measures ANOVA); #p < 0.05, thresholds on the test day compared with thresholds on the preconditioning day (paired t test). B, Percentage of change from baseline ICSS thresholds ± SEM in morphine-dependent unpaired rats injected with saline instead of naloxone during conditioning sessions.