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. 2005 Jun 29;25(26):6105–6118. doi: 10.1523/JNEUROSCI.1432-05.2005

Figure 2.

Figure 2.

Dendrite arbors are reduced in adult abl-/-, arg-/-, and bs-dko mice. A-D, Camera lucida drawings of representative wild-type (A), abl-/- (B), arg-/- (C), and bs-dko (D) layer 5 pyramidal neurons from 6- to 8-week-old mice. Apical and basal dendrite arbors are indicated for a wild-type neuron in A. E, F, Sholl analysis of apical (E) and basal (F) dendrites from wild-type, abl-/-, arg-/-, and bs-dko layer 5 pyramidal neurons. Sholl analysis measures dendrite complexity: concentric three-dimensional shells of increasing radius are centered on the cell body of the neuron; the number of intersections of the dendrite arbor with a given shell is plotted versus the shell radius. Each point represents mean ± SE. For all data presented in this figure, analysis was performed on the following: apical dendrites, wild type, n = 6 mice, 16 neurons; abl-/-, n = 4 mice, 15 neurons; arg-/-, n = 4 mice, 16 neurons; bs-dko, n = 6 mice, 17 neurons; basal dendrites, wild type, n = 6 mice, 16 neurons; abl-/-, n = 4 mice, 16 neurons; arg-/-, n = 4 mice, 17 neurons; bs-dko, n = 6 mice, 16 neurons. G, H, Mean total length (G) and branchpoint number (H) of apical (left) and basal (right) dendrite arbors from wild-type, abl-/-, arg-/-, and bs-dko layer 5 pyramidal neurons. Mean ± SE. ANOVA between all genotypes: apical length, p = 0.233; basal length, p = 0.014; apical branchpoints, p = 0.092; basal branchpoints, p < 0.0001; post hoc Student-Newman-Keuls test for each mutant versus wild type, *p < 0.05.