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. 2005 Jun 29;25(26):6066–6075. doi: 10.1523/JNEUROSCI.1168-05.2005

Figure 2.

Figure 2.

Neuronal responses of BLA-responsive mPFC neurons to test presentations of the CS+ versus CS- olfactory stimuli. A, Neuronal activity traces of a single mPFC neuron showing preconditioning (before footshock pairings) versus postconditioning neuronal responses to CS+ versus CS- odors over 10 s of odor presentation. A strong increase in neuronal activity is observed in this neuron, specifically in response to the CS+ odor after conditioning. B, Neuronal activity traces of a single mPFC neuron comparing preconditioning baseline activity to postconditioning spontaneous activity to presentations of the CS- versus CS+ odors (see Materials and Methods). Open bars represent presentation of the CS- odor, whereas the black bar represents the presentation of the CS+ odor for this and all subsequent graphs. A dramatic increase in neuronal activity is observed specifically in response to the CS+ odor after conditioning. C, Mean number of spontaneous spikes from BLA-responsive neurons (n = 24) during the 10 s conditioning trials over time (see Materials and Methods). BLA-responsive mPFC neurons show significant increases in activity in response to the CS+ odor by the second conditioning trial and all subsequent trials (*p < 0.05 for this and all subsequent graphs). In contrast, these neurons showed a significant decrease from trial 1 responding relative to trial 4 responding to the CS-. BL, Baseline. Error bars represent SEM.