Figure 3.

Discharge profile and pattern of an Nb-labeled cholinergic neuron. A, Across sleep-wake (S-W) states (shown in the sleep-wake hypnogram), the Nb+/ChAT+ cell (Figs. 1 A, 2, #c30u13) discharged at variable rates (shown in unit rate histogram) in association with variable EEGs (shown in power spectral array). B, Its average discharge rate was moderately high in aW, minimal in SWS, and maximal in PS. C, Its discharge pattern was rhythmic during aW, tPS, and PS (shown in the ACHs). D, Its firing was significantly cross-correlated with the EEG during PS on both the RS and PF cortex (evident in the Unit-to-EEG STA in red compared with the shuffled train in gray). E, Its rhythmic discharge occurred in high-frequency bursts of spikes (∼143 Hz) at regular intervals corresponding to a theta oscillation (according to the first and second smoothed modes of the ISIH for PS). F, Its EEG-correlated discharge occurred at a theta frequency with a peak of 7 Hz (evident in the power spectra of the Unit-to-EEG STA shown in red) that also corresponded to the prominent peak of the EEG activity (in blue) on both the RS cortex and the PF cortex during PS.