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Antidepressant-like effect of MCH1R antagonism. The effect on latency to immobility (a) and total swimming time (b) on day 1 of the FST was investigated in MCH-KO mice versus wild-type (WT) mice. The same analysis was performed in rats (day 2, FST) that received injections of MCH1R antagonist (antag.) [0.5 μg/side (c, d) or 1.0 μg/side (e, f)] directly into the AcSh. *p < 0.05; **p < 0.01; n = 5-9 per group. Error bars indicate SEM.
