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Expression of human apoE3 or apoE4 delays deposition compared with murine apoE in the APPsw model at 12 months of age. A, D, Anti-Aβ immunostaining with monoclonal antibody m3D6 (A) or X-34 staining (D) to denote fibrillar amyloid of APPsw mice expressing endogenous murine apoE demonstrating CAA (arrows) and parenchymal plaques (arrowheads). However, 12-month-old (12 m.o.) APPsw mice expressing human apoE3 (B, E) or apoE4 (C, F) had little or no detectable plaques.
