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. 2005 Mar 16;25(11):2803–2810. doi: 10.1523/JNEUROSCI.5170-04.2005

Figure 3.

Figure 3.

Expression of apoE determines the level of CAA and parenchymal plaque pathology in an isoform-dependent manner in the 15-month-old (15 m.o.) APPsw model. A-F, Anti-Aβ immunostaining with m3D6 antibody (A-C) or X-34 staining (D-F) to visualize fibrillar Aβ deposits demonstrates CAA (arrows) and parenchymal plaques (arrowheads). A, D, APP swmice expressing endogenous murine apoE had both CAA and parenchymal plaques. B, C, E, F, APPsw mice expressing human apoE3 (B, E) had only occasional Aβ deposits, whereas APPsw mice expressing human apoE4 (C, F) had extensive CAA with infrequent parenchymal plaques.