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. 2005 Mar 16;25(11):2803–2810. doi: 10.1523/JNEUROSCI.5170-04.2005

Figure 6.

Figure 6.

Expression of human apoE4 (hApoE4) alters the ratio of Aβ 40:42 in extracellular pools of the CNS. A, The level of Aβ1-40 in PBS-soluble brain extracts was significantly higher in APPsw mice expressing human apoE4 compared with mice expressing murine apoE (mApoE). Aβ1-42 levels were slightly, but not significantly, lower in APPsw mice expressing human apoE4 compared with mice expressing murine apoE. B, The level of Aβ1-40 in the CSF was slightly, but not significantly, lower in APPsw mice expressing human apoE4 compared with mice expressing murine apoE. Also, Aβ1-42 levels were slightly, but not significantly, higher in APPsw mice expressing human apoE4 compared with mice expressing murine apoE. C, The Aβ 40:42 ratio in PBS-soluble extracts was significantly higher in APPsw mice expressing human apoE4 compared with murine apoE. D, However, the Aβ 40:42 ratio in the CSF was significantly lower in APPsw mice expressing human apoE4 compared with mice expressing human apoE3 or murine apoE. Error bars represent SEM.