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. 2005 Mar 16;25(11):2885–2894. doi: 10.1523/JNEUROSCI.2748-04.2005

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Copyright © 2005 Society for Neuroscience 0270-6474/05/252885-10.00/0

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Figure 6. — A, Quantification of PLP/DM20 mRNA-positive oligodendrocytes in the corpus callosum in 28-d-old mice. The total numbers of mRNA PLP/DM20-positive oligodendrocytes per sagittal section were counted. The greatest decrease in oligodendrocytes number (90%) was observed in mice treated continuously from P1 to P28. Oligodendrocyte number was decreased by 67 and 59% in transgenic mice treated from P1 to P7 and P7 to P14, respectively. The reduction was less (34%) in mice treated from P14 to P21. B, The total number of BrdU⁺ cells was counted after immunohistochemistry with a monoclonal antibody to BrdU. A reduction of 80% of the total BrdU-positive cells in the entire surface of the corpus callosum was observed at P10 in GCV-treated mice compared with control. This reduction was ∼64% at P20. Results are expressed as means ± SE (n = 3 mice/group; 3 sections/mouse).