Figure 4.

Visualization of a voxel-based statistical analysis. Compared with the vigilance task, the BP of [¹¹C]FLB 457 decreased during the working memory task bilaterally in the VLFC (left, p = 0.008; right, p = 0.02) (A-C) and in the left medial temporal lobe (p < 0.01) (D). Compared with the resting state baseline, both the vigilance task (p = 0.001) (E) and the working memory task (p < 0.001) (F) induced a decrease in the BP of [¹¹C]FLB 457 in the left ventral AC. All p values have been corrected for multiple comparisons. The results are visualized on a brain model (top) and on an average MRI template image (bottom) and presented in line with the neurological convention (right is right).