Table 1.

Brain metabolite analysis determined by in vivo brain ¹H-MRS and ³¹P-MRS

Metabolite ratio	Uninfected mice	CM mice
1H-MRS (TE, 16 ms)	n = 9	n = 12
NAA/S	0.35 ± 0.08	0.28 ± 0.06*
tCr/S	0.16 ± 0.01	0.17 ± 0.03
Cho/S	0.13 ± 0.02	0.13 ± 0.02
Glx/S	0.20 ± 0.05	0.28 ± 0.06**
Taurine/S	0.05 ± 0.02	0.04 ± 0.01
myo-inositol/S	0.11 ± 0.04	0.10 ± 0.03
1H-MRS (TE, 135 ms)	n = 9	n = 12
NAA/S	0.37 ± 0.06	0.28 ± 0.02***
tCr/S	0.30 ± 0.03	0.29 ± 0.02
Cho/S	0.33 ± 0.04	0.33 ± 0.03
Lactate/S	0.01 ± 0.02	0.09 ± 0.05***
31P-MRS	n = 8	n = 8
PCr/β-ATP	2.46 ± 0.41	2.73 ± 0.50
PCr/Pi	6.83 ± 0.44	5.63 ± 0.33
β-ATP/Pi	2.9 ± 0.95	2.08 ± 0.25
(PCr + β-ATP)/Pi	9.73 ± 2.15	7.71 ± 1.02*
pH	7.29 ± 0.09	7.11 ± 0.09*

Values are reported as means ± SD (^*p < 0.05; ^**p < 0.005; ^***p < 0.0005).