Correlation of anxiety with PAG activity during visceral pain. a, The mean PAG parameter estimate for visceral and somatic pain; no significant difference in activation was observed. a, b, Anxiety during the painful visceral stimuli correlated with right (R) PAG activity (b; r = 0.74; p < 0.05; Pearson's r, two-tailed) and approached significance for the left (L) PAG (a; r = 0.66; p = 0.08; Pearson's r, two-tailed).