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. 2005 Jan 19;25(3):758–767. doi: 10.1523/JNEUROSCI.3909-04.2005

Figure 1.

Figure 1.

NT-3 prevents the development of thermal hyperalgesia but not mechanical sensitivity associated with CCI. Hyperalgesic index plots represent alterations in thermal (A, B) and mechanical (C, D) sensitivities in response to 7 d CCI without (A, C) or with (B, D) 7 d NT-3 intrathecal infusion. Dashed line indicates the time of unilateral CCI. A, Thermal hyperalgesia is significantly increased compared with baseline levels after CCI and is maintained for the duration of the experiment (n = 7). B, Infusion of NT-3 significantly attenuates the development of thermal hyperalgesia after CCI and is maintained for the duration of the infusion (***p < 0.0001, relative to CCI alone; n = 5). The solid arrow indicates the start of NT-3 infusion. C, Mechanical hypersensitivity is significantly increased compared with baseline levels after unilateral CCI and is maintained for the duration of the experiment (7 d; n = 7). D, Infusion of NT-3 does not alter the mechanical hypersensitivity that develops after unilateral CCI (7 d; n = 5). The solid arrow indicates the start of NT-3 infusion.