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Emergence of NG2-immunoreactive cells in pdgfra-null mouse brain. a, Wild-type (wt) and homozygous αR2-4-null (-/-) littermates at embryonic day 13.5; the inset is a horizontal section of mutant cranium showing the prominent cleft palate. b, Horizontal section of day 16.5 pdgfra-null mutant showing highly branched NG2+ cells in brain cortex (arrows). c, d, NG2 cells with morphology of migrating OPCs in day 19 wild-type and mutant littermates. Scale bar, 100 μm.
