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. 2005 Apr 6;25(14):3509–3520. doi: 10.1523/JNEUROSCI.3929-04.2005

Figure 3.

Figure 3.

Effect of calibrated reduction in sodium conductance on bursting in Purkinje neurons. A, Dose-response relationship for TTX inhibition of sodium current in Purkinje neurons. Sodium current was measured as the peak current elicited using a voltage step from -75 to -10 mV. Each point in A shows current relative to control averaged over five cells, except for 100 nm TTX (complete block in 2 cells). The solid line is drawn according to 1/(1 + [TTX]/2.7 nm). The external solution consisted of the following (in mm): 50 NaCl, 105 TEACl, 4 KCl, 2 CaCl2, 2 MgCl2, and 10 HEPES, pH 7.4 with ∼5 NaOH. B, Effects of increasing degrees of sodium current block on all-or-none burst firing in a Purkinje cell. Concentrations of TTX were selected to produce 25, 50, and 75% block of sodium current. The external solution consisted of the following (in mm): 155 NaCl, 4 KCl, 2 CaCl2, 2 MgCl2, and 10 HEPES, pH 7.4 with ∼5 NaOH.