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Go-protein subunits modulate neuronal nAChR channel activity. A, Modulation of nAChR single-channel activity recorded from an inside-out membrane patch during receptor activation with 5 μm ACh in the absence (control) and presence of 50 nm Goα or Gβγ subunits. Holding potential was -60 mV. B, Effect of both G-protein subunits on NPo and closed-time distributions obtained from four excised membrane patches (mean ± SEM; **p < 0.01).
