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. 2005 Apr 6;25(14):3701–3711. doi: 10.1523/JNEUROSCI.4346-04.2005

Figure 6.

Figure 6.

Activation of primary microglia by cMMP-3. Primary mouse microglia were also activated by cMMP-3 in an ERK-dependent manner. Primary mouse microglia were treated with either various concentration of cMMP-3 alone (125, 250, and 400 ng/ml) or combined pretreatment with inhibitors. U0126 (20 μm) or NNGH (60 μm) were 30 min pretreated before cMMP-3 (400 ng/ml). TNF-α release was measured at 3 and 8 h after treatment. Control, Untreated; LPS, LPS at 10 ng/ml; 125, 250, 400, cMMP-3 at 125, 250, and 400 ng/ml, respectively; NNGH+cMMP-3, 30 min pretreatment of NNGH (60 μm) and then cMMP-3 (400 ng/ml); U0126+cMMP-3, 30 min pretreatment of U0126 (20 μm) and then cMMP-3 (400 ng/ml). Values represent the mean ± SD (n = 4).