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. 2005 Apr 6;25(14):3628–3637. doi: 10.1523/JNEUROSCI.4480-04.2005

Figure 3.

Figure 3.

Expression of plexin-A4 in the forebrain and defects in the anterior commissure and the barrel formation in plexin-A4 mutant mice. A, Expression of plexin-A4 in the forebrain of an embryo at E13.5, detected by whole-mount ISH. Strong ISH signals are detected in the anterior olfactory nucleus (AON), the lateral telencephalon (LT), and the trigeminal ganglion (TG) but not the olfactory bulb (OB). B-D, The anterior commissure in adult wild-type and plexin-A4 mutant mice. Horizontal sections were stained with Luxol fast blue to detect myelinated fibers and counterstained with cresyl violet. E, F, The acA tract of the anterior commissure in wild-type and plexin-A4 mutant mice at P1. Serial coronal sections were immunostained with an anti-Tag-1 antibody. The sections are aligned in the rostrocaudal order from a to d. Arrowheads indicate the acA tracts. Asterisks indicate the lateral olfactory tract. G-J, The barrels detected by histochemistry for cytochrome oxidase in coronal (G, H) and tangential (I, J) sections of adult brains of wild-type (G, I) and plexin-A4 mutant (H, J) mice. Scale bars: A-D, 1 mm; E-J, 500 μm.