Figure 5.

Dependence of interval and duration of episodes on g_syn and τ_d/τ_v. A, τ_d/τ_v = 1. a, Duration (open circles) and interval (filled squares) of episodes obtained from simulations for different g_syn values. Data for duration (interval) is normalized to the duration (interval) value at g_syn = 33 pS (control value, also used in Fig. 6). b, Two-parameter response diagrams show how the right knee and the left knee shift with g_syn. The bistability range (range of values covered by Cl_i during episodic behavior) increases with decreasing g_syn; consequently, both interval and duration increase with decreasing g_syn. Double arrows indicate the Cl_i range covered during episodic activity, for two values of g_syn (33 and 27 nS). B, τ_d/τ_v = 4. a, Duration and interval for different g_syn values. b, Two-parameter response diagrams show how the RK and LK (thick lines) and the HC and HB (thin lines) shift with g_syn. Contrary to the previous case, Cl_i covers the range between HC and RK during episodic activity (double arrows; shown for g_syn = 33 and 27 nS). With decreasing g_syn, this range does not increase as much as in A, so interval and durations are less affected.