Figure 1.

Spontaneous coiling behavior is defective in sho embryos. A, Individual frames from a time-lapse video showing two consecutive coils by a wild-type sibling embryo (22 hpf). Each coil lasted ∼500 ms and is denoted by an arrow. Time of each frame is shown at the top right corner. Scale bar, 0.5 mm. B, The frequency of coiling is reduced at all stages in sho embryos (circles) compared with wild-type siblings (wtsib; squares). ^*p < 0.001 by Student's t test. Error bars are SDs.