Figure 7.

Partial block of glycinergic inhibitory synaptic transmission can restore swimming in sho embryos, but the response to mechanosensory stimulation is still aberrant. A, A series of muscle voltage recordings from a wild-type embryo in response to mechanosensory stimulation (arrow) after exposure to different concentrations of strychnine. i, Rhythmic depolarizations are elicited in the absence of strychnine. ii, An irregular, large depolarization is elicited in 10 μm strychnine. iii, An irregular, large depolarization is elicited in 50 μm strychnine. B, A series of muscle recordings from a sho embryo in response to mechanosensory stimulation (arrow) after exposure to different concentrations of strychnine. i, A typical sho-like depolarization is elicited. ii, An irregular, large depolarization followed by rhythmic depolarizations (bracket) similar to swimming is elicited in 10 μm strychnine. iii, Only an irregular, large depolarization is elicited in 50 μm strychnine. wtsib, Wild-type sibling.