Figure 3.

Neonatal infection increases hippocampal gene expression of glial cell markers in adulthood. Adult rats treated on P4 with PBS (black bars) or E. coli (white bars) were injected with saline (SAL) or LPS as adults, and brains were collected 1–24 h later. Data for CD11b (a), GFAP (b), IL-1β (c), and IL-10 (d) mRNA are presented as mean ± SEM relative expression to a housekeeping gene (GAPDH). a, CD11b expression was higher overall and specifically at baseline (24 h after saline) and 8 and 24 h after LPS in rats infected with E. coli as neonates compared with controls. b, GFAP expression was higher overall and specifically 8 and 24 h after LPS in rats infected with E. coli as neonates; *p < 0.05 for all.