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. 2005 Sep 7;25(36):8217–8228. doi: 10.1523/JNEUROSCI.1859-05.2005

Figure 7.

Figure 7.

Migration of neuronal progenitor cells in EAE-induced mice treated with GA. DCX-expressing neuronal progenitors (orange) diverge from the classic neuroproliferative zones or the migratory streams and spread to atypical regions along YFP-expressing fibers (green). A, From the RMS into the striatum. B, C, Toward the region of the nucleus accumbens, from the SVZ (B) and from the RMS (C). D, From the RMS into the internal part of the cortex to layer 5 (E) and layer 6 (F). Note the morphological features of the DCX-expressing cells, fusiform somata with leading and trailing processes (C, inset, E, F), characteristic of migrating neurons, and their orientation, migration away from the migratory stream, along the nerve fibers (A, D–F). Figures represent five GA-treated mice (sagittal sections). Scale bar: A–D, 200 μm; E, 100 μm; F, 10 μm. In A–C, the enlarged box area is depicted in the right panel. St, Striatum; AC, anterior commissure; cc, corpus callosum; L-5 and L-6, layers five and six of the cerebral cortex.