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. 2005 Sep 7;25(36):8217–8228. doi: 10.1523/JNEUROSCI.1859-05.2005

Figure 9.

Figure 9.

Migration of neuronal progenitors to lesion sites. DCX-expressing cells (orange) were found in injured regions with deterioration of YFP-expressing fibers (green). A, EAE mice (not treated by GA), 35 d after disease induction, in the striatum. B–F, EAE mice, 35 d after disease induction, treated by GA (8 daily injections, starting immediately after disease induction, prevention). DCX-expressing cells are shown diverging from the RMS toward a lesion in the striatum (B), surrounding a lesion in the striatum (C), inside a lesion in the frontal cortex layer 5/6 (D, E), and in a cluster surrounding a lesion in the nucleus accumbens (F). Lesions in GA-treated mice were less extensive than those in untreated mice, yet the amount of progenitors adjoining these lesions was extensively higher. Note the YFP-expressing fibers extending into the lesions and the axonal sprouting in lesions occupied by DCX-expressing cells (D–F). Representative figures from four EAE and five EAE+GA mice (sagittal sections). Scale bar: A, B, 100 μm; C, D, F, 50 μm; E, 20 μm.