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. 2005 Oct 26;25(43):10016–10024. doi: 10.1523/JNEUROSCI.2520-05.2005

Figure 2.

Figure 2.

Synaptic GABAA receptor-mediated currents are not altered during epilepsy. A, Representative mIPSC traces recorded from interneurons and pyramidal cells from control and epileptic rats in the presence of tetrodotoxin (1 μm). B, C, Summary histograms of the amplitude and decay time constant of mIPSCs recorded in different cell types. The amplitude of mIPSCs was significantly larger in interneurons than in pyramidal cells in the epileptic hippocampus. No significant change was observed across cell types between control and epileptic rats. D, Representative sIPSC traces recorded from interneurons and pyramidal cells from control and epileptic rats. E, F, Summary histograms of the amplitude and decay time constant of sIPSCs recorded as in D. The amplitude of sIPSCs was larger in control pyramidal cells than in interneurons. This difference was maintained after epilepsy. The monoexponential decay time constant of sIPSCs was similar in all the cell types. *p < 0.05; **p < 0.01; ***p < 0.001. Error bars represent SEM.