Figure 10.

Effect of repeated intrathecal injection of PDGFRα/Fc on thermal hyperalgesia or tactile allodynia induced by a single intrathecal injection of thrombin in normal mice. Groups of mice were repeatedly treated intrathecally with PDGFRα/Fc (10 ng/mouse) or sterile PBS 1 h before the single intrathecal injection of thrombin (1 pmol/mouse) and once per day for 12 consecutive days after injection. Each point indicates the mean ± SEM of six mice. sec, Seconds; i.t., intrathecal. ^**p < 0.01 and ^***p < 0.001 versus PBS-PBS group; ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001 versus PBS-Thrombin group. Error bars represent SEM.