Figure 8.

A-C, Effect of repeated intrathecal injection of an inhibitor of PDGF receptor-mediated PTK, AG17, on thermal hyperalgesia (A) and tactile allodynia (B, C) in sham-operated or nerve-ligated mice. sec, Seconds. B, C, Tactile stimulus was applied using filaments with two different bending forces [0.02 g (B) and 0.16 g (C)]. Groups of mice were repeatedly treated intrathecally with AG17 (30 nmol/mouse) or vehicle 30 min before surgery (day 0) and once per day for 8 consecutive days after surgery. Each point represents the mean ± SEM of five to seven mice. ^**p < 0.01 and ^***p < 0.001 versus Vehicle-Sham group; ^##p < 0.01 and ^###p < 0.001 versus Vehicle-Ligation group. Error bars represent SEM.