Figure 6.

Expression of PIP₂ sequestering or degrading constructs reduces whole-cell Kv7.2/7.3 current amplitudes. CHO cells were cotransfected with Kv7.2+Kv7.3 together with either GFP only (control) or the PLCδ PH, Lyn-PH-PP, or Akt-PH constructs. Currents were elicited using the indicated voltage protocol in whole-cell configuration. A, Plotted are superimposed current traces from four different cells transfected with each different construct. B, Bars show the mean whole-cell current amplitudes for these four groups of cells. ^**p < 0.01; ^***p < 0.001.