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. 2005 Oct 26;25(43):9871–9882. doi: 10.1523/JNEUROSCI.2590-05.2005

Figure 6.

Figure 6.

Effect of cAMP on thalamic activity modes. TC neurons were recorded under current-clamp conditions. Action potential firing was elicited by 300 ms depolarizing current pulses (50-75 pA) from a holding potential of about -71 mV. Calibration bars: 100 ms, 20 mV. A, D, Endogenous and exogenous increases in intracellular cAMP levels by application of IBMX (100 μm; A) and 8-bromo-cAMP (1 mm; D) resulted in a reversible depolarization of the membrane potential. The horizontal bars indicate duration of substance application. B, C, E, F, Under control conditions (top voltage traces), depolarizing current steps elicited burst responses in both rat strains. Application of IBMX (B, C; middle traces) and 8-bromo-cAMP (E, F; middle traces) resulted in a change from burst to tonic firing only in ACI (B, E) but not WAG/Rij (C, F) rats.