Figure 11.

PMA treatment enhances camphor-activated currents in DRG neurons. A, Ramp currents from –100 to +100 mV at baseline before PMA addition (dashed line) and after a 16 s application of 1 μm PMA application (red line). The application of 10 mm camphor (blue line) and 1 μm capsaicin (solid black line) after PMA treatment elicited large ramp currents similar to heterologously expressed TRPV1. B, The current at +80 mV (triangles) and –80 mV (squares) during voltage ramps in the cell in A is plotted. The positions of the ramp currents displayed in A are indicated by the green symbols. The dotted line indicates zero current level.