Figure 7.
Camphor-activated IrTRPV1 exhibits fast acute desensitization and strong tachyphylaxis. A, B, IrTRPV1 activated by 10 mm camphor quickly and completely desensitized during an ∼60 s application. Capsaicin-activated currents desensitized with much slower kinetics and less completely. C, Camphor-activated inward IrTRPV1 underwent very strong tachyphylaxis, giving much smaller response on repeated applications of 10 mm camphor. D, In contrast, ITRPV3 was slightly sensitized after repeated stimulation with 4 mm camphor.