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. 2005 Sep 28;25(39):8867–8877. doi: 10.1523/JNEUROSCI.2541-05.2005

Figure 6.

Figure 6.

Modulation of Ih by 8-Br-cAMP. A, B, Representative current traces recorded before (a) and after (b) bath application of 8-Br-cAMP (0.6 mm). Recordings were made in the same cells. A, High CF neurons; B, middle CF neurons. C, D, Fast (a) and slow (b) time constants and the fraction of the fast component (c) were plotted. For C–F, Filled symbols, Control; open symbols, 8-Br-cAMP. C, High CF neurons; D, middle CF neurons. In the middle CF neurons, the fast time constant was slightly shortened, but the slow time constant was not affected (p > 0.07). E, F, Voltage-dependent activation curves. In high CF neurons (E), Vh = –95.5 and S = 9.8 mV for control; Vh = –85.4 and S = 10.6 mV in 8-Br-cAMP (p < 0.01). In middle CF neurons (F), Vh = –85.8 and S = 10.1 mV for control; Vh = –82.6 and S = 10.0 mV in 8-Br-cAMP (p < 0.05).