Table 1.

Differences among the three CF neurons with regard to the membrane potential and properties of I_h

	High CF	Middle CF	Low CF
Resting membrane potentials (mV)a
Controlb	-63.0 ± 0.5 (9)	-62.2 ± 0.5 (29)	-61.6 ± 0.7 (31)
ZD7288 (0.1 mm)	-63.4 ± 0.6 (9)	-64.7 ± 0.9 (12)*	-64.8 ± 0.6 (23)*
Properties of Ihc
Maximum current amplitudes (nA)d
Instantaneous	-0.7 ± 0.1 (15)	-1.8 ± 0.1 (26)	-4.6 ± 0.7 (8)
Steady-state	-2.7 ± 0.2 (15)	-5.2 ± 0.2 (26)	-11.7 ± 1.6 (8)
Activation kinetics (ms)e
τfastf	52.2 ± 3.2 (13)	31.4 ± 1.4 (26)	29.9 ± 3.9 (9)
τslowf	313.3 ± 39.3 (13)	162.8 ± 13.0 (26)	142.7 ± 16.5 (8)
Vh (mV)f	-95.5 ± 0.6 (15)	-85.8 ± 0.5 (26)	-85.8 ± 2.8 (8)
S (mV)b	9.8 ± 0.3 (15)	10.1 ± 0.3 (26)	9.3 ± 0.3 (8)

Numbers in parentheses are the numbers of cells.

^*Statistically significant difference (p < 0.05 by unpaired t test) compared with the control in each CF.

^a Data are from current-clamp experiments (Figs. 3, 4).

^b Difference was not significant among the three CF neurons (p > 0.27).

^c Data are from voltage-clamp experiments (Fig. 5).

^d Current amplitude was measured at -143 mV step pulse (Fig. 5). Difference was significant among the three CF regions (p < 0.01).

^e Activation kinetics were measured at -123 mV step pulse (Fig. 5).

^f Difference was significant between high CF neurons and neurons in the other two regions (p < 0.01) but was not significant between middle CF and low CF neurons (p > 0.1).