Figure 5.

Inflammation-induced enhancement of tau phosphorylation. A, Immunoblotting analysis of total tau (HT7) and phosphorylated tau (AT8) in PBS- and LPS-treated 3xTg-AD mice, with β-actin used as a protein loading control. Data represent at least five mice per group. B, Immunohistochemical staining of total human tau and phosphorylated tau in hippocampal neurons of 3xTg-AD mice treated with PBS and LPS. The inset in the bottom right panel is a magnified view of AT8-immunopositive neurons in the hippocampus.