Table 2.

Refinement statistics

	Aniracetam	CX614
Resolution (Å)	30.0-1.65	30.0-1.70
Rwork (%)a	19.9	20.9
Rfree (%)b	22.1	22.3
# Protein atoms	4024	11776
# Water molecules	711	776
# Ligand atoms	62	196
Mean B value (Å2)	18.3	19.2
rms deviations from ideality: bonds/angles (Å/°)	0.005/1.22	0.005/1.20

^cIn the refinements, there were two aniracetam and two fluorowillardiine molecules in the Ani/FW complex and six CX614 and six quisqualate molecules in the CX614/Quis complex.

^a R_work = (Σ∥F_o| - |F_c∥)/Σ|F_o|, where F_o and F_c denote observed and calculated structure factors, respectively.

^b Ten percent of the reflections were set aside for calculation of R_free.