Table 1.
Slower kinetics of 2pEPSCs rather than mEPSCs is partially caused by activation of AMPA receptors in neighboring synapses
|
|
2pEPSCs |
|
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total |
Hot spot distance >2.3 μm |
Hot spot distance <2.3 μm |
||||||||||
| Shutter duration |
1 ms |
2 ms |
1 ms |
2 ms |
1 ms |
2 ms |
mEPSCs |
|||||
| 10-90% rise (ms) | 3.03 ± 0.19 (n = 76) | 3.88 ± 0.36 (n = 22) | 2.81 ± 0.26** (n = 36) | 3.20 ± 0.36** (n = 13) | 3.22 ± 0.26 (n = 40) | 4.86 ± 0.58* (n = 9) | 0.72 ± 0.06 ms (n = 107) | |||||
| 62% decay (ms) |
20.4 ± 1.2 (n = 70) |
25.4 ± 4.7 (n = 22) |
15.7 ± 1.3** (n = 36) |
19.1 ± 1.5** (n = 13) |
25.3 ± 1.7** (n = 34) |
34.5 ± 10.8 (n = 9) |
4.0 ± 0.6 ms (n = 106) |
|||||
The kinetics of 2pEPSCs from hot spots isolated >2.3 μm was significantly faster than that from total hot spots but still had slower kinetics than that of mEPSCs. Some values for hot spots isolated <2.3 μm were significantly slower than those for total hot spots. Values were not corrected for RC filtering and are expressed as mean ± SEM. The number of hot spots for 2pEPSCs and the number of events for mEPSCs are indicated in parentheses. *p < 0.05; **p < 0.01 (Bonferroni's multiple t test).