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. 2005 Nov 30;25(48):11165–11174. doi: 10.1523/JNEUROSCI.4031-05.2005

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Copyright © 2005 Society for Neuroscience 0270-6474/05/2511165-10.00/0

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Figure 5. — Cerebrovascular oxidative stress in APP⁺ and TGF⁺ mice, or AD. A, SOD2 immunoreactivity in wild-type (WT) mice is found in neurons and distributes in small puncta (arrows in left inset) within the cytoplasm, consistent with a mitochondrial localization of the enzyme. SOD2 is upregulated in perivascular cuffs and rims (open arrows) in both 4- and 12-month-old APP⁺ mice but not or only slightly (open arrows in right inset) in 18- to 21-month-old TGF⁺ mice. mo, Month. B, SOD2 immunoreactivity in elderly, nondemented controls distributes primarily in neurons (also located in small punctate structures; arrow in top inset) with a slight perivascular location (open arrows; bottom insets). In contrast, in AD tissues, SOD2 is upregulated in glial cells without any apparent increase in perivascular staining (open arrows; bottom inset). Scale bars: A, 75 μm; B, 40 μm.