Skip to main content
. 2005 Nov 30;25(48):11125–11132. doi: 10.1523/JNEUROSCI.2545-05.2005

Figure 2.

Figure 2.

Increased invasion of peripheral cells into the neocortex of amyloid-depositing APP23 mice. A, Neocortex of a 16-month-old control mouse and 16-month-old APP23 mouse showing the distribution of GFP-positive cells (here immunostained with an antibody to GFP). Congophilic plaques are shown in red. Scale bar, 100 μm. The inset shows a GFP-positive cell closely associated with an amyloid plaque. B, GFP-positive cells were morphologically classified in five distinct subgroups. Scale bars, 20 μm. C, Quantification of total GFP-positive cells revealed a 52% increase (*p < 0.05) in the neocortex of APP23 mice compared with control mice (shown are results for group 1) (Fig. 1). When GFP cells were subgrouped, only ameboid cells were significantly increased (sevenfold; p = 0.002). Similar analysis for groups 2 and 3 also revealed significant increases in ameboid cells (p = 0.006 and p = 0.01, respectively) but not any other cell subtype. No differences in total number or any subgroup of GFP-positive cells were found in young, predepositing APP23 mice (group4) (Fig.1). Error bars represent SD of the total number of GFP-positive cells.